Tag Archives: Stephen Hill

Targacept’s pioneering target proves too elusive

I had the good fortune of covering Targacept, a pioneering drug-discovery company that spun out of R&D at R.J. Reynolds Tobacco Co., since its founding in 2000. Don deBethizy, the first CEO, placed a good bit of trust in me as a journalist with the Business Journal and allowed me extraordinary access to his strategic thinking and his top scientists.

Targacept promised to revolutionize the treatment of mankind’s most vexing neurological disorders by harnessing the most advantageous properties of nicotine. It was an audacious plan that attracted hundreds of millions of dollars in investment of venture capitalists, public markets and individual investors. It was also, after 15 years, more than 20 drug trials and $300 million spent, a complete and utter failure.

My February 2015 column in the Triad Business Journal is an obituary of sorts for the company and the pharmacological concept that eluded it. At this link, you will find a Q&A I conducted with Targacept’s second and final CEO, Stephen Hill. Finally, here is a link to my WFDD radio report on the failure of Targacept.